La Tour du Valat

Institut de recherche pour la conservation des zones humides méditerranéennes

Titre :	Regulation of 3 beta-HSD activity in the songbird brain
Auteurs :	Devaleena S. Pradhan, Auteur ; Kiran K. Soma, Auteur
Type de document :	Article
Dans :	Journal of Ornithology (153 AUG 2012)
Article en page(s) :	S227-S234
Langues:	Anglais
Résumé :	Birds show high levels of steroid synthesis in the brain. Steroid biosynthesis in the brain can provide a mechanism for local and rapid changes in steroid levels in particular brain regions. Neural steroidogenic enzymes are regulated on both short and long timescales by both endogenous and environmental factors. Here, we discuss the regulation of one steroidogenic enzyme, 3 beta-hydroxysteroid dehydrogenase/Delta 5-Delta 4 isomerase (3 beta-HSD), which activates the prohormone dehydroepiandrosterone by converting it to a potent and aromatizable androgen, androstenedione. First, brain 3 beta-HSD mRNA and activity are regulated by developmental stage in nestling Zebra Finches (Taeniopygia guttata). Second, in vitro estradiol rapidly (

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