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La Tour du Valat

Institut de recherche pour la conservation des zones humides méditerranéennes

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Titre :	Are the mammalian-like uncoupling proteins 1 and 2 expressed in cold-acclimated Muscovy ducklings?
Auteurs :	F. Denjean, Auteur ; J. Lachuer, Auteur ; F. Cohen-adad, Auteur ; H. Barre, Auteur ; C. Duchamp, Auteur
Type de document :	Article
Dans :	Ornis Fennica (76(4) 1999)
Article en page(s) :	167-175
Langues:	Anglais
Résumé :	Despite their lack of brown adipose tissue (BAT), birds can exhibit nonshivering thermogenesis (NST) in the cold. Avian NST mainly originates from skeletal muscle and may involve fatty acid-induced uncoupling of mitochondrial respiration. In mammals, uncoupling of oxidative phosphorylation is based on the presence of uncoupling proteins (UCPs) in the inner mitochondrial membrane. Because both the BAT-specific UCP1 and the ubiquitous UCP2 are up-regulated in cold-acclimated (CA) rodents, the question arises as to whether CA birds exhibiting NST express mammalian-like UCPs. Tissue expression of UCP1 and UCP2 mRNA was therefore investigated in CA Muscovy ducklings (Cairina moschata, 5-wk old), reared at 4 degrees C from the age of l-wk and exhibiting muscle NST. Rat fragments of UCP1 or UCP2 cDNA were used as probes in Northern blots. UCP1 mRNA was detected only in rat BAT while UCP2 mRNA was detected in rat BAT, liver and soleus muscle. Conversely, no UCP1- or UCP2-like mRNA were detected in duckling skeletal muscle, white adipose tissue and liver. It is concluded that CA ducklings do not express a mRNA with sufficient homology to hybridise with rat UCP1 or UCP2 probes.

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